Title of article
Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity
Author/Authors
Zixia Feng، نويسنده , , Suchismita Mohapatra، نويسنده , , Peter G. Klimko، نويسنده , , Mark R. Hellberg، نويسنده , , Jesse A. May، نويسنده , , Curtis Kelly، نويسنده , , Gary Williams، نويسنده , , Marsha A. McLaughlin، نويسنده , , Najam A. Sharif، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2998
To page
3002
Abstract
A series of 8-substituted benzodifuran analogs was prepared and evaluated for 5-HT2A receptor binding and activation. Several compounds containing ether and ester functionality were found to be potent agonists. Topical ocular administration of 5, 18, and 25 effectively reduced intra-ocular pressure in the hypertensive cynomolgus monkey eye in the range of 25–37%.
Keywords
Oxadiazole , Benzodifuran , IOP , (R)-DOI , Glaucoma , 5-HT2 agonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798164
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