Title of article
Synthesis and structure–activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2
Author/Authors
Ginny D. Ho، نويسنده , , Ana Bercovici، نويسنده , , Deen Tulshian، نويسنده , , William J. Greenlee، نويسنده , , Ahmad Fawzi، نويسنده , , Xiomara Fernandez، نويسنده , , Robbie L. McLeod، نويسنده , , April Smith-Torhan، نويسنده , , Hongtao Zhang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
3028
To page
3033
Abstract
A series of 4-[2-(aminomethyl)phenyl]-1-[bis(2-chlorophenyl)methyl]-4-hydroxypiperidine analogs has been identified as nociceptin receptor ligands. These compounds display high affinity and functional activity at the nociceptin receptor. The synthesis and structure–activity relationships at the C-4 phenyl and N-1 positions are described and the antitussive activity of a selected compound is reported.
Keywords
KOP , DOP) , Nociceptin , Orphnin FQ , Nociceptin receptor (NOP) , G protein-coupled receptor , Opioid receptor-like-1 (ORL-1) , Opioid receptors (MOP
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798171
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