Author/Authors :
Upender Velaparthi، نويسنده , , Peiying Liu، نويسنده , , Balu Balasubramanian، نويسنده , , Joan Carboni، نويسنده , , Ricardo Attar، نويسنده , , Marco Gottardis، نويسنده , , Aixin Li، نويسنده , , Ann Greer، نويسنده , , Mary Zoeckler، نويسنده , , Mark D. Wittman، نويسنده , , Dolatrai Vyas، نويسنده ,
Abstract :
A series of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) were examined in which the pendant imidazole moiety was replaced to improve selectivity for IGF-1R inhibition over cytochrome P450 (CYP). Synthesis and SAR of these compounds is presented.
Keywords :
nsulin-like growth factor-1 receptor , IGF-1R , tyrosine kinase , imidazole , CYP450 inhibition , imidazoline , Pyridone , Benzimidazole
