Author/Authors :
Dahui Zhou، نويسنده , , Nicole T. Hatzenbuhler، نويسنده , , Jonathan L. Gross، نويسنده , , Boyd L. Harrison، نويسنده , , Deborah A. Evrard، نويسنده , , Michael Chlenov، نويسنده , , Jeannette Golembieski، نويسنده , , Geoffrey Hornby، نويسنده , , Lee E. Schechter، نويسنده , , Deborah L. Smith، نويسنده , , Terrance H. Andree، نويسنده , , Gary P. Stack، نويسنده ,
Abstract :
Structural modifications of the initial lead, 3-aminochroman (4), led to the identification of a novel series of pyridyl-fused amino chroman derivatives (5–8) and the structural isomers (9–12). The compounds described were evaluated for dual 5-HT transporter inhibitory and 5-HT1A receptor activities. The design strategy, synthesis, and in vitro biological characterization for these novel compounds are described.
