Title of article
Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor
Author/Authors
Liqiang Chen، نويسنده , , Guangyao Gao، نويسنده , , Laurent Bonnac، نويسنده , , Daniel J. Wilson، نويسنده , , Eric M. Bennett، نويسنده , , Hiremagalur N. Jayaram، نويسنده , , Krzysztof W. Pankiewicz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
3152
To page
3155
Abstract
A methylenebis(sulfonamide) linked NAD analogue has been designed to circumvent the metabolically unstable, ionic nature of the natural pyrophosphate linkage. This NAD analogue is assembled through two Mitsunobu reactions of a methylenebis(sulfonamide) linker with two protected nucleosides. A 2,4-dimethoxybenzyl group is used as a sulfonamide protective group, which allows facile removal under mildly acidic conditions. This NAD analogue inhibits IMPDH at low micromolar concentration.
Keywords
Inosine monophosphate dehydrogenase , Pyrophosphate mimics , NAD analogue , IMPDH , Methylenebis(sulfonamide)
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798195
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