Title of article :
Synthesis, biological evaluations, and tubulin binding poses of C-2α sulfur linked taxol analogues
Author/Authors :
Lei Wang، نويسنده , , Ana A. Alcaraz، نويسنده , , Ruth Matesanz، نويسنده , , Chun-Gang Yang، نويسنده , , Isabel Barasoain، نويسنده , , J. Fernando D?az، نويسنده , , Ye-Zhi Li، نويسنده , , James P. Snyder، نويسنده , , Wei-Shuo Fang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
In combination with chemical modifications, bioassays, and computational simulation techniques, C-2 benzoylthio, and benzylthio taxoids were synthesized, biologically evaluated, and their binding conformations rationalized, in order to probe the interaction of taxane molecule with β-tubulin.
Keywords :
Paclitaxel , Taxol analogues , Binding conformation , SAR studies
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
