مرکز منطقه ای اطلاع رساني علوم و فناوري - 4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation

Title of article :

4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation

Author/Authors :

Terry V. Hughes، نويسنده , , Stuart L. Emanuel، نويسنده , , Amanda K. Beck، نويسنده , , Steven K. Wetter، نويسنده , , Peter J. Connolly، نويسنده , , Prabha Karnachi، نويسنده , , Michael Reuman، نويسنده , , Jabed Seraj، نويسنده , , Angel R. Fuentes-Pesquera، نويسنده , , Robert H. Gruninger، نويسنده , , Steven A. Middleton، نويسنده , , Ronghui Lin، نويسنده , , Jeremy M. Davis، نويسنده , , David F.C. Moffat، نويسنده ,

Issue Information :

روزنامه با شماره پیاپی سال 2007

Pages :

From page :

3266

To page :

3270

Abstract :

A novel series of 4-aryl-5-cyano-2-aminopyrimidines were synthesized and found to have potent VEGF-R2 kinase inhibitory activity. Structure–activity relationships were investigated and compound 14a was shown to be efficacious in a mouse model of corneal neovascularization.

Keywords :

kinase , VEGF-R2 , kdr , cancer , angiogenesis , kinase inhibitor , 2-Aminopyrimidines

Journal title :

Bioorganic & Medicinal Chemistry Letters

Serial Year :

2007

Journal title :

Bioorganic & Medicinal Chemistry Letters

Record number :

798217

Link To Document :

https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=798217