Title of article
4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation
Author/Authors
Terry V. Hughes، نويسنده , , Stuart L. Emanuel، نويسنده , , Amanda K. Beck، نويسنده , , Steven K. Wetter، نويسنده , , Peter J. Connolly، نويسنده , , Prabha Karnachi، نويسنده , , Michael Reuman، نويسنده , , Jabed Seraj، نويسنده , , Angel R. Fuentes-Pesquera، نويسنده , , Robert H. Gruninger، نويسنده , , Steven A. Middleton، نويسنده , , Ronghui Lin، نويسنده , , Jeremy M. Davis، نويسنده , , David F.C. Moffat، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3266
To page
3270
Abstract
A novel series of 4-aryl-5-cyano-2-aminopyrimidines were synthesized and found to have potent VEGF-R2 kinase inhibitory activity. Structure–activity relationships were investigated and compound 14a was shown to be efficacious in a mouse model of corneal neovascularization.
Keywords
kinase , VEGF-R2 , kdr , cancer , angiogenesis , kinase inhibitor , 2-Aminopyrimidines
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798217
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