Title of article
Chipping at large, potent human T-cell leukemia virus type 1 protease inhibitors to uncover smaller, equipotent inhibitors
Author/Authors
Tooru Kimura، نويسنده , , Jeffrey-Tri Nguyen، نويسنده , , Hikoichiro Maegawa، نويسنده , , Keiji Nishiyama، نويسنده , , Yasuhiro Arii، نويسنده , , Yasuko Matsui، نويسنده , , Yoshio Hayashi، نويسنده , , Yoshiaki Kiso، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3276
To page
3280
Abstract
The human T-cell leukemia virus type 1 (HTLV-I) causes adult T-cell leukemia and several severe chronic diseases. HTLV-I protease (PR) inhibition stops the propagation of the virus. Herein, truncation studies were performed on potent octapeptidic HTLV-I PR inhibitor KNI-10161 to derive small hexapeptide KNI-10127 with some loss in activity. After performing residue-substitution studies on compound KNI-10127, HTLV-I PR inhibitory activity was recovered in inhibitor KNI-10166.
Keywords
Human T-cell leukemia virus , Human immunodeficiency virus , Adult T-cell leukemia , protease inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798219
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