Title of article
Benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides as inhibitors of carbonic anhydrase
Author/Authors
Virginija Dudutien?، نويسنده , , Lina Baranauskien?، نويسنده , , Daumantas Matulis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
3335
To page
3338
Abstract
A series of benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides were synthesized and their binding to two carbonic anhydrase isozymes measured by isothermal titration calorimetry (ITC). Human carbonic anhydrase I (hCAI) and bovine carbonic anhydrase II (bCAII) bound the inhibitors with observed association constants in the range from 1.1 × 106 to 2.6 × 107 M−1.
Keywords
Aromatic sulfonamides , Binding enthalpy , Carbonic anhydrase , Observed binding constant , inhibition
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798230
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