Author/Authors :
Baolin Wu&Hongyu Zhao، نويسنده , , Michael D. Serby، نويسنده , , Harriet T. Smith، نويسنده , , Ning Cao، نويسنده , , Tom S. Suhar، نويسنده , , Teresa K. Surowy، نويسنده , , Heidi S. Camp، نويسنده , , Christine A. Collins، نويسنده , , Hing L. Sham، نويسنده , , Gang Liu، نويسنده ,
Abstract :
A series of novel stearoyl-CoA desaturase 1 (SCD1) inhibitors were identified by scaffold design based on known SCD1 inhibitors. Large structural changes were made leading to multiple analogs with comparable or improved potency. This approach is valuable for generation of proprietary compounds without conducting a costly high-throughput screening.
