Title of article
Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors
Author/Authors
Baolin Wu&Hongyu Zhao، نويسنده , , Michael D. Serby، نويسنده , , Harriet T. Smith، نويسنده , , Ning Cao، نويسنده , , Tom S. Suhar، نويسنده , , Teresa K. Surowy، نويسنده , , Heidi S. Camp، نويسنده , , Christine A. Collins، نويسنده , , Hing L. Sham، نويسنده , , Gang Liu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
3388
To page
3391
Abstract
A series of novel stearoyl-CoA desaturase 1 (SCD1) inhibitors were identified by scaffold design based on known SCD1 inhibitors. Large structural changes were made leading to multiple analogs with comparable or improved potency. This approach is valuable for generation of proprietary compounds without conducting a costly high-throughput screening.
Keywords
Molecule design , Scaffold manipulation , SCD1 inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798240
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