Author/Authors :
Qun Dang، نويسنده , , Yan Liu، نويسنده , , Robert M. Rydzewski، نويسنده , , Brian S. Brown، نويسنده , , Edward Robinson، نويسنده , , Paul D. van Poelje، نويسنده , , Timothy J. Colby، نويسنده , , Mark D. Erion، نويسنده ,
Abstract :
A series of substituted bis[(para-methoxy)benzyl] (bisPMB) esters of 1-naphthalenemethylphosphonate (NMPA) were synthesized and evaluated as phosphonate prodrugs. BisPMB NMPA esters (4b and 4c) with significantly improved aqueous stability were identified that also resulted in increased intracellular levels of NMPA following prodrug incubation with primary rat hepatocytes.
