Author/Authors :
Katarina Flyrén، نويسنده , , Lars O. Bergquist، نويسنده , , Victor M. Castro، نويسنده , , Christopher Fotsch، نويسنده , , Lars Johansson، نويسنده , , David J. St. Jean Jr.، نويسنده , , Lori Sutin، نويسنده , , Meredith Williams، نويسنده ,
Abstract :
A series of piperidine amide inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) were identified via modifications of the HTS hit compound 1. The synthesis, in vitro biological evaluation, and structure–activity relationship of these compounds are presented.
