Title of article
Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors
Author/Authors
Hiroshi Maruoka، نويسنده , , Tsuyoshi Muto، نويسنده , , Taisaku Tanaka، نويسنده , , Seiichi Imajo، نويسنده , , Yoshiaki Tomimori، نويسنده , , Yoshiaki Fukuda، نويسنده , , Takashi Nakatsuka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3435
To page
3439
Abstract
A novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones was designed, synthesized, and evaluated as human chymase inhibitors. From this series, we identified several compounds which were effective, via oral administration, in a mouse model of chronic dermatitis.
Keywords
Chymase , inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798250
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