Title of article
Bradykinin B1 antagonists: Biphenyl SAR studies in the cyclopropanecarboxamide series
Author/Authors
Scott D. Kuduk، نويسنده , , Robert M. DiPardo، نويسنده , , Ronald K. Chang، نويسنده , , Christina N. Di Marco، نويسنده , , Kathy L. Murphy، نويسنده , , Richard W. Ransom، نويسنده , , Duane R. Reiss، نويسنده , , Cuyue Tang، نويسنده , , Thomayant Prueksaritanont، نويسنده , , Douglas J. Pettibone، نويسنده , , Mark G. Bock، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3608
To page
3612
Abstract
SAR study of the biphenyl region of cyclopropanecarboxamide derived bradykinin B1 antagonists was examined. Incorporation of a pyridine in place of the proximal phenyl ring and chlorination of the distal phenyl ring proved to be well tolerated and provided compounds with improved pharmacokinetic profiles, CNS penetration, and enhanced receptor occupancy.
Keywords
bradykinin , B1 , Antagonists , biphenyl
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798280
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