Title of article
Biaryl cannabinoid mimetics—Synthesis and structure–activity relationship
Author/Authors
Karin Worm، نويسنده , , Q. Jean Zhou، نويسنده , , Gabriel J. Stabley، نويسنده , , Robert N. DeHaven، نويسنده , , Roland E. Dolle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3652
To page
3656
Abstract
Synthesis, in vitro biological evaluation, and structure–activity relationships of a biaryl cannabinoid mimetic 2 are reported. Variations in the substitution pattern yielded a number of agonists with low nanomolar affinity. Replacing the phenol group by a methyl morpholino acetate group led to compound 28, a 500-fold selective CB2 receptor agonist.
Keywords
Structure–activity relationships , Cannabinoid CB2 receptors , Cannabinoid CB1 receptors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798288
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