Title of article :
Cytotoxic effects of C-glycosides in HOS and HeLa cell lines
Author/Authors :
Carlos A. Sanhueza، نويسنده , , Carlos Mayato، نويسنده , , Rubén P. Mach?´n، نويسنده , , José M. Padr?n، نويسنده , , Rosa L. Dorta، نويسنده , , Jes?s T. V?zquez، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Fifty-two C-glycosides were synthesized and their in-vitro antiproliferative activity screened against human cervical carcinoma (HeLa) and osteosarcoma (HOS) cell lines. Nine of them had growth inhibitions (GI50 values) below 10 μM, the C-glucopyranoside 38 being the most active against HeLa (5.4 μM) and the dichlorocyclopropyl derivative 42 against HOS (1.6 μM). Some preliminary structure–activity relationships were established.
Keywords :
Cytotoxic , cancer , C-Glycosides , 2-Keto-C-glycosides , C-Mannosides , Osteosarcoma (HOS) , Cervical carcinoma (HeLa)
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
