Title of article
Synthesis and local anesthetic activity of fluoro-substituted imipramine and its analogues
Author/Authors
Wen Li، نويسنده , , Qidong You، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
3
From page
3733
To page
3735
Abstract
A series of fluoro-substituted imipramines and its analogues, 6a–6e, were synthesized and evaluated for their in vitro local anesthetic activity. Compound 6b was found to have potency, onset, and duration of action comparable to those of lidocaine (lidocaine hydrochloride, CAS:6108-05-0). Dissociation constants (pKa) of these compounds have been determined to be 7.6–7.9.
Keywords
Fluoro-substituted imipramine , Local anesthetic activity , Lidocaine , Dissociation constants , synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798304
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