Author/Authors :
Takashi Yamamoto، نويسنده , , Koichi Fujita، نويسنده , , Sayaka Asari، نويسنده , , Akira Chiba، نويسنده , , Yuka Kataba، نويسنده , , Koji Ohsumi، نويسنده , , Naoko Ohmuta، نويسنده , , Yuko Iida، نويسنده , , Chiori Ijichi، نويسنده , , Satoshi Iwayama، نويسنده , , Naoyuki Fukuchi، نويسنده , , Masataka Shoji، نويسنده ,
Abstract :
A series of isoxazole derivatives were synthesized and their antagonistic activities against LPA stimulation on both LPA1/CHO cells and rHSC cells were evaluated. Among them, 3-(4-{4-[1-(2-chloro-cyclopent-1-enyl)-ethoxycarbonylamino]-isoxazol-3- yl}-benzylsulfanyl)-propionic acid (34) showed the most potent activities.
Keywords :
Lysophosphatidic acid , Isoxazole derivative , LPA antagonists , Liver fibrosis , Lysophosphatidic acid receptor (LPA1)
