Title of article
Design and synthesis of novel hydantoin-containing melanin-concentrating hormone receptor antagonists
Author/Authors
Fabrice Balavoine، نويسنده , , Patrice Malabre، نويسنده , , Thierry Alleaume، نويسنده , , Astrid Rey، نويسنده , , Valérie Cherfils، نويسنده , , Olivier Jeanneton، نويسنده , , Sophie Seigneurin-Venin، نويسنده , , Frédéric Revah، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
3754
To page
3759
Abstract
We report here new chemical series acting as antagonists of melanin-concentrating hormone receptor 1 (MCHR-1). Synthesis and structure–activity relationships are described leading to the identification of compounds with optimized in vitro pharmacological and in vitro ADME profiles. In vivo activity has been demonstrated in animal models of food intake and depression.
Keywords
Hydantoin , Melanin-concentrating hormone , MCHR-1 antagonists , obesity , feeding , depression
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798309
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