Title of article
4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives as non-peptidic selective δ-opioid agonists with potential anxiolytic/antidepressant properties. Part 2
Author/Authors
Andrés A. Trabanco، نويسنده , , Nancy Aerts، نويسنده , , Rosa M. Alvarez، نويسنده , , José I. Andrés، نويسنده , , Inge Boeckx، نويسنده , , Javier Fernandez-Suarez، نويسنده , , Antonio G?mez، نويسنده , , Frans E. Janssens، نويسنده , , Joseph E. Leenaerts، نويسنده , , Ana I. De Lucas، نويسنده , , Encarna Matesanz، نويسنده , , Thomas Steckler، نويسنده , , Shirley Pullan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
3860
To page
3863
Abstract
Novel 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives have been prepared and their synthesis described herein. In vitro affinities for δ-, μ-, and κ-opioid receptors are reported. Evaluation of some representative compounds from this series in the mouse neonatal ultrasonic vocalization test and the mouse tail suspension test revealed anxiolytic- and antidepressant-like effects, respectively, upon subcutaneous administration.
Keywords
Anxiolytic , Antidepressant , ?-Agonist , Opioid
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798327
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