Title of article
Co-crystal structure guided array synthesis of PPARγ inverse agonists
Author/Authors
Ryan P. Trump، نويسنده , , Jeffrey E. Cobb، نويسنده , , Barry G. Shearer، نويسنده , , Millard H. Lambert and H. Eric Xu، نويسنده , , Robert T. Nolte، نويسنده , , Timothy M. Willson and Shawn P. Williams، نويسنده , , Richard G. Buckholz، نويسنده , , Sumin M. Zhao، نويسنده , , Lisa M. Leesnitzer، نويسنده , , Marie A. Iannone، نويسنده , , Kenneth H. Pearce، نويسنده , , Andrew N. Billin، نويسنده , , William J. Hoekstra، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3916
To page
3920
Abstract
PPARγ-activating thiazolidinediones and carboxylic acids such as farglitazar exert their anti-diabetic effects in part in PPARγ rich adipose. Both pro- and anti-adipogenic PPARγ ligands promote glucose and lipid lowering in animal models of diabetes. Herein, we disclose representatives of an array of 160 farglitazar analogues with atypical inverse agonism of PPARγ in mature adipocytes.
Keywords
PPAR? , inverse agonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798338
Link To Document