Title of article :
Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors
Author/Authors :
Tomomi Noguchi-Yachide، نويسنده , , Atsushi Aoyama، نويسنده , , Makoto Makishima، نويسنده , , Hiroyuki Miyachi، نويسنده , , Yuichi Hashimoto، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
α-Glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity. Novel LXR antagonists with a 2′-substituted phenylphthalimide skeleton were obtained by structural development of glucosidase inhibitors derived from thalidomide.
Keywords :
Phthalimide , thalidomide , Liver X receptor (LXR) , Glucosidase , Antagonist
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
