Title of article
Synthesis and characterization of a perchlorotriphenylmethyl (trityl) triester radical: A potential sensor for superoxide and oxygen in biological systems
Author/Authors
Vinh Dang، نويسنده , , Jinhua Wang، نويسنده , , Song Feng، نويسنده , , Christophe Buron، نويسنده , , Frederick A. Villamena، نويسنده , , Peng George Wang، نويسنده , , Periannan Kuppusamy، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
4062
To page
4065
Abstract
Synthesis and characterization of an inert perchlorotriphenylmethyl triester radical, PTM-TE, are reported. PTM-TE was prepared by a facile 3-step synthesis using Friedel-Crafts reaction of tetrachlorobenzene with chloroform followed by ethoxycarbonylation and subsequent oxidation. PTM-TE is paramagnetic and exhibits a single sharp EPR spectrum. In solution, the EPR linewidth of PTM-TE is highly sensitive to the dissolved oxygen content, thus enabling accurate measurement of oxygen concentration (oximetry). In addition, the radical also shows high reactivity towards superoxide. The ester radical has the potential for use as a high-sensitive probe for determination of oxygen concentration and superoxide in biological systems.
Keywords
Perchlorotriphenylmethyl radical , Perchlorotriphenylmethyl triester , oximetry , Spectrophotometry , Superoxide , EPR , free radicals
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798369
Link To Document