Author/Authors :
Cecile Pegurier، نويسنده , , Philippe Collart، نويسنده , , Pierre Danhaive، نويسنده , , Sabine Defays، نويسنده , , Michel Gillard، نويسنده , , Frédéric Gilson، نويسنده , , Thierry Kogej، نويسنده , , Patrick Pasau، نويسنده , , Nathalie Van houtvin، نويسنده , , Marc Van Thuyne، نويسنده , , BerendJan van Keulen، نويسنده ,
Abstract :
The discovery and optimization of a novel class of potent CCR3 antagonists is described. Details of synthesis and SAR are given together with some ADME properties of selected compounds. An optimal balance between activities, physicochemical properties, and in vitro metabolic stability was reached by the proper choice of substituents.
Keywords :
Chemokine , CCR3 , Pyrazolone , asthma
