Title of article
Pyrazolone methylamino piperidine derivatives as novel CCR3 antagonists
Author/Authors
Cecile Pegurier، نويسنده , , Philippe Collart، نويسنده , , Pierre Danhaive، نويسنده , , Sabine Defays، نويسنده , , Michel Gillard، نويسنده , , Frédéric Gilson، نويسنده , , Thierry Kogej، نويسنده , , Patrick Pasau، نويسنده , , Nathalie Van houtvin، نويسنده , , Marc Van Thuyne، نويسنده , , BerendJan van Keulen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
4228
To page
4231
Abstract
The discovery and optimization of a novel class of potent CCR3 antagonists is described. Details of synthesis and SAR are given together with some ADME properties of selected compounds. An optimal balance between activities, physicochemical properties, and in vitro metabolic stability was reached by the proper choice of substituents.
Keywords
Chemokine , CCR3 , Pyrazolone , asthma
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798400
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