Title of article
Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents
Author/Authors
Ronghui Lin، نويسنده , , Peter J. Connolly، نويسنده , , Yanhua Lu، نويسنده , , George Chiu، نويسنده , , Shengjian Li، نويسنده , , Yang Yu، نويسنده , , Shenlin Huang، نويسنده , , Xun Li، نويسنده , , Stuart L. Emanuel، نويسنده , , Steven A. Middleton، نويسنده , , Robert H. Gruninger، نويسنده , , MARY ADAMS، نويسنده , , Angel R. Fuentes-Pesquera، نويسنده , , Lee M. Greenberger، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
4297
To page
4302
Abstract
A series of 3,5-disubstituted pyrazolo[3,4-b]pyridine cyclin-dependent kinase (CDK) inhibitors was synthesized. These compounds showed potent and selective CDK inhibitory activities and inhibited in vitro cellular proliferation in cultured human tumor cells. Selected compounds were evaluated in an in vivo tumor xenograft model. The synthesis and biological evaluation of these pyrazolo[3,4-b]pyridines and related compounds are reported.
Keywords
cyclin dependent kinase inhibitor , 4-b]pyridine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798413
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