Title of article
Discovery of novel prostaglandin analogs of PGE2 as potent and selective EP2 and EP4 receptor agonists
Author/Authors
Yufang Xiao، نويسنده , , Gian Luca Araldi، نويسنده , , Zhong Zhao، نويسنده , , Nadia Brugger، نويسنده , , Srinivasa Karra، نويسنده , , David Fischer، نويسنده , , Elizabeth Palmer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
4323
To page
4327
Abstract
Analogs of PGE2 with introduction of diene groups at the ω-side chain have been synthesized and evaluated for their binding affinity for EP2 and EP4 receptors. An optimized analog (compound 9b) showed high potency and selectivity for the EP4 receptor over other known receptors.
Keywords
Prostaglandin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798418
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