Discovery of novel prostaglandin analogs of PGE2 as potent and selective EP2 and EP4 receptor agonists

Analogs of PGE2 with introduction of diene groups at the ω-side chain have been synthesized and evaluated for their binding affinity for EP2 and EP4 receptors. An optimized analog (compound 9b) showed high potency and selectivity for the EP4 receptor over other known receptors.