Title of article :
Design, synthesis, and molecular modeling studies of 5′-deoxy-5′-ureidoadenosine: 5′-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase
Author/Authors :
Ting Wang، نويسنده , , Hyun Joo Lee، نويسنده , , Dilip K. Tosh، نويسنده , , Hea Ok Kim، نويسنده , , Shantanu Pal، نويسنده , , Sun Choi، نويسنده , , Yoonji Lee، نويسنده , , Hyung Ryong Moon، نويسنده , , Long-Xuan Zhao، نويسنده , , Kang Man Lee، نويسنده , , Lak Shin Jeong، نويسنده ,
Abstract :
5′-Deoxy-5′-ureidoadenosine was designed and synthesized as a potent inhibitor of S-adenosylhomocysteine hydrolase (SAH), in which 5′-ureido group acted as multiple hydrogen bonding donor in binding with active site residues of SAH in the molecular modeling study.
