Title of article
Gypsophin: A novel α-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana
Author/Authors
Jian-Guang Luo، نويسنده , , Xiaobing WANG، نويسنده , , Li Ma، نويسنده , , Ling-yi Kong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
4460
To page
4463
Abstract
An unusual new cyclic peptide with a pyrrolidine-2,5-dione unit, gypsophin (1), was isolated from Gypsophila oldhamiana. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was determined by application of the Marfey’s method and the single-crystal X-ray diffraction. Compound 1 exhibited inhibitory activity against α-glucosidase with IC50 of 305 μM.
Keywords
Caryophyllaceae , Cystallographic data , ?-Glucosidase inhibitor , Gypsophin , Cyclic peptide , Gypsophila oldhamiana
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798443
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