Title of article :
Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor
Author/Authors :
Lydie Poitout، نويسنده , , Valérie Brault، نويسنده , , Carole Sackur، نويسنده , , Sonia Bernetière، نويسنده , , José Câmara، نويسنده , , Pascale Plas، نويسنده , , Pierre Roubert، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A novel series of benzimidazoles was identified and optimized, leading to the discovery of potent and selective antagonists of the human melanocortin-4 receptor. In addition, compound 5i was shown to cross the blood–brain barrier after intravenous dosing in rats.
Keywords :
Benzimidazole , Melanocortin-4 receptor , Antagonist
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
