Title of article :
Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae
Author/Authors :
Elena Cressina، نويسنده , , Adrian J. Lloyd، نويسنده , , Gianfranco De Pascale، نويسنده , , David I. Roper، نويسنده , , Christopher G. Dowson، نويسنده , , Timothy D.H. Bugg، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Adenosine and 2′-deoxyadenosine phosphonate transition state analogues act as the first inhibitors for the MurMN/FemABX family of tRNA-dependent ligases implicated in high-level penicillin resistance in Gram-positive bacteria.
Keywords :
Streptococcus pneumoniae , MurM , inhibitor , Antibacterial , peptidoglycan biosynthesis
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
