Title of article
Synthesis and evaluation of potent and selective β3 adrenergic receptor agonists containing heterobiaryl carboxylic acids
Author/Authors
Barry G. Shearer، نويسنده , , Esther Y. Chao، نويسنده , , David E. Uehling، نويسنده , , David N. Deaton، نويسنده , , Conrad Cowan، نويسنده , , Bryan W. Sherman، نويسنده , , Tula Milliken، نويسنده , , Walter Faison، نويسنده , , Kathleen Brown، نويسنده , , Kimberly K. Adkison، نويسنده , , Frank Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
8
From page
4670
To page
4677
Abstract
The design, synthesis, and SAR of a novel series of heterobiaryl phenethanolamine β3 adrenergic receptor agonists are described. The furan analogue 49 was shown to elicit a significant dose-dependent lowering of plasma glucose in a rodent model of type 2 diabetes.
Keywords
Diabetes , agonist , ?3 Adrenergic receptor , Selective
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798483
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