Title of article :
Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists
Author/Authors :
Yukiyoshi Yamazaki، نويسنده , , Kazutoyo Abe، نويسنده , , Tsutomu Toma، نويسنده , , Masahiro Nishikawa، نويسنده , , Hidefumi Ozawa، نويسنده , , Ayumu Okuda، نويسنده , , Takaaki Araki، نويسنده , , Soichi Oda، نويسنده , , Keisuke Inoue، نويسنده , , Kimiyuki Shibuya، نويسنده , , Bart Staels، نويسنده , , Jean-Charles Fruchart، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A combination of benzoxazole, phenoxyalkyl side chain, and phenoxybutyric acids was identified as a highly potent and selective human peroxisome proliferator-activated receptor α (PPARα) agonist. The synthesis, structure–activity relationship (SAR) studies, and in vivo activities of the representative compounds are described.
Keywords :
design , PPAR?-selective , structure–activity relationship , synthesis , Triglyceride , Lipid abnormalities , HDL-cholesterol , Nuclear receptor , fibrates , PPAR?
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
