Title of article
Synthesis, in vitro and in vivo cytotoxicity of 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones
Author/Authors
F. Scott Kimball، نويسنده , , Ashok Rao Tunoori، نويسنده , , Samuel F. Victory، نويسنده , , Dinah Dutta، نويسنده , , Jonathan M. White، نويسنده , , Richard H. Himes، نويسنده , , Gunda I. Georg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
4703
To page
4707
Abstract
A 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-one library was constructed and tested against the colon cancer cell line HCT-116 as an initial screen for cytotoxic properties. Of this library, the parent compound, in which the southern aromatic ring remains unsubstituted, and the northern aromatic ring carries a 4-methoxy group, exhibited the most potent cytotoxicity with an IC50 value of 0.39 μM and displayed promising activity in vivo in the NCI’s mouse hollow fiber assay.
Keywords
Seco-phenanthroindolizidine alkaloids , colon cancer , NCI mouse hollow fiber assay , Compare analysis , HCT-116
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798489
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