Title of article :
Pyridinylimidazole inhibitors of Tie2 kinase
Author/Authors :
Marcus Semones، نويسنده , , Yanhong Feng، نويسنده , , Neil Johnson، نويسنده , , Jerry L. Adams، نويسنده , , Jim Winkler، نويسنده , , Michael Hansbury، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.
Keywords :
Tie2 kinase , imidazole , xenograft
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
