Author/Authors :
Makoto Ubukata، نويسنده , , Hitomi Takamori، نويسنده , , Misaki Ohashi، نويسنده , , Shinya Mitsuhashi، نويسنده , , Kaoru Yamashita، نويسنده , , Tomohisa Asada، نويسنده , , Noriyuki Nakajima، نويسنده , , Nobuyasu Matsuura، نويسنده , , Mie Tsuruga، نويسنده , , Keiko Taki، نويسنده , , Junji Magae، نويسنده ,
Abstract :
Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated receptor γ (PPARγ).
Keywords :
Mycophenolic acid , PPAR? , 3T3-L1 , IMPDH , inhibitor , SPR
