Title of article :
Synthesis and structure–activity relationship of novel RXR antagonists: Orally active anti-diabetic and anti-obesity agents
Author/Authors :
Junichi Sakaki، نويسنده , , Masashi Kishida، نويسنده , , Kazuhide Konishi، نويسنده , , Hiroki Gunji، نويسنده , , Atsushi Toyao، نويسنده , , Yuki Matsumoto، نويسنده , , Takanori Kanazawa، نويسنده , , Hidefumi Uchiyama، نويسنده , , Hiroaki Fukaya، نويسنده , , Hironobu Mitani، نويسنده , , Yoshie Arai، نويسنده , , Masaaki Kimura، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Pages :
4
From page :
4804
To page :
4807
Abstract :
A series of diazepinylbenzoic acid derivatives were synthesized and tested in the inhibition assay of the transactivation of RXR. Oral treatment of cyano derivatives (16f) was found to show anti-diabetic and anti-obesity effects in KK-Ay mice.
Keywords :
RXR , Antagonist , Anti-diabetic , Anti-obesity
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2007
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
798505
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=798505
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