Title of article
4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors
Author/Authors
Micheal D. Gaul، نويسنده , , Guozhang Xu، نويسنده , , Jennifer Kirkpatrick، نويسنده , , Heidi Ott، نويسنده , , Christian A. Baumann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
4861
To page
4865
Abstract
A series of 4-amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes has been discovered and developed as potent FLT3 tyrosine kinase inhibitors. The series exhibited potent antiproliferative activity against both an FLT3 ITD-mutated human leukemic cell line as well as a wild-type FLT3 BaF3 expressed cell line. The structure–activity relationship of this class of compounds is described.
Keywords
Antiproliferative , FLT3 tyrosine kinase , Acute myeloid leukemia
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798517
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