Title of article
Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators
Author/Authors
Nicholas C. Ray، نويسنده , , Robin D. Clark، نويسنده , , David E. Clark، نويسنده , , Karen Williams، نويسنده , , H.G. Hickin، نويسنده , , Peter H. Crackett، نويسنده , , Hazel J. Dyke، نويسنده , , Peter M. Lockey، نويسنده , , Melanie Wong، نويسنده , , René Devos، نويسنده , , Anne White، نويسنده , , Joseph K. Belanoff، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
4901
To page
4905
Abstract
A virtual screening approach comprising a 3-D similarity search based on known GR modulators was used to identify a novel series of non-steroidal glucocorticoid receptor (GR) antagonists. Optimization of the initial hit to provide potent compounds which exhibit good selectivity against other steroidal nuclear hormone receptors is described.
Keywords
Glucocorticoid , depression , Psychotic , Antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798525
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