Title of article
Sulfenamides as prodrugs of NH-acidic compounds: A new prodrug option for the amide bond
Author/Authors
Victor R. Guarino، نويسنده , , Veranja Karunaratne، نويسنده , , Valentino J. Stella، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
4910
To page
4913
Abstract
The objective of this report is to introduce the novel concept of utilizing sulfenamides as prodrugs for compounds containing an NH-acidic functionality, particularly weakly acidic amide-type functionalities (amides, ureas, carbamates, etc.). Included are the syntheses and physicochemical characterizations of some model sulfenamides to illustrate the promise of this new prodrug technology.
Keywords
sulfenamide , NH-acid , Solubility , bioavailability , Dissolution rate , permeability , stability , prodrug , Amide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798527
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