Interaction of O-(undec-10-en)-yl-d-glucose derivatives with the Plasmodium falciparum hexose transporter (PfHT)

All-O-undec-en-10-yl derivatives of d-glucose have been prepared and their affinities for the Plasmodium falciparum hexose transporter (PfHT) determined; the O-2 derivative displays a good apparent affinity for PfHT (KI = 2 μM) with no significant interaction with the mammalian transporter GLUT1. This selectivity points to position −2 of glucose as an appropriate substitution site for the development of inhibitors of P. falciparum glucose uptake.