Title of article
Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I
Author/Authors
Xinming Li، نويسنده , , Magdeline Tao Tao Ng، نويسنده , , Yifan Wang، نويسنده , , Xiaoqian Liu، نويسنده , , Tianhu Li، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
4967
To page
4971
Abstract
A dumbbell-shaped circular oligonucleotide containing topoisomerase I-binding sites and two mismatched base pairs in its sequence has been designed and synthesized. Our further studies demonstrate that this particularly designed oligonucleotide displays an IC50 value of 9 nM in its inhibition on the activity of human topoisomerase I, a magnitude smaller than that of camptothecin, an anticancer drug currently in clinical use.
Keywords
Circular oligonucleotides , Human topoisomerase I , Enzyme inhibitor , Stable hairpins
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798538
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