Title of article
New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET
Author/Authors
Johnny Vercouillie، نويسنده , , Winnie Deuther-Conrad، نويسنده , , Matthias Scheunemann، نويسنده , , Patrick Emond، نويسنده , , Steffen Fischer، نويسنده , , Uta Funke، نويسنده , , J?rg Steinbach، نويسنده , , Denis Guilloteau، نويسنده , , Peter Brust، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
4991
To page
4995
Abstract
A series of fluorinated diphenylchalcogen derivatives, possessing a sulfur or an oxygen bridge, has been prepared with the aim to get a suitable radiotracer to image the SERT in vivo using positron emission tomography (PET). The compounds were synthesized and assayed toward the serotonin (SERT), dopamine (DAT), and norepinephrine (NET) transporters. Among the developed series, five compounds display a high SERT affinity (Ki: 0.27–2.91 nM range) and can be labeled either with carbon-11 or fluorine-18.
Keywords
SERT , PET , Diphenylsulfides , Affinity , Selectivity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798543
Link To Document