Author/Authors :
Adam R. Renslo، نويسنده , , Andy Atuegbu، نويسنده , , Prudencio Herradura، نويسنده , , Priyadarshini Jaishankar، نويسنده , , Mingzhe Ji، نويسنده , , Karen L. Leach، نويسنده , , Michael D. Huband، نويسنده , , Michael R. Dermyer، نويسنده , , Luping Wu، نويسنده , , J.V.N. Vara Prasad، نويسنده , , Mikhail F. Gordeev، نويسنده ,
Abstract :
Oxazolidinone analogs bearing substituted piperidine or azetidine C-rings are described. Analogs with a methyl group at the 3-position of the azetidine ring or the 4-position of the piperidine ring exhibited reduced mitochondrial protein synthesis inhibition while retaining good antibacterial potency.
Keywords :
Antibacterials , Oxazolidinones , Selectivity , Mitochondrial protein synthesis inhibition , Azetidines , piperidines
