Title of article
Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists
Author/Authors
Hidenori Takahashi، نويسنده , , Younes Bekkali، نويسنده , , Alison J. Capolino، نويسنده , , Thomas Gilmore، نويسنده , , Susan E. Goldrick، نويسنده , , Paul V. Kaplita، نويسنده , , Lisa Liu، نويسنده , , Richard M. Nelson، نويسنده , , Donna Terenzio، نويسنده , , Ji Wang، نويسنده , , Ljiljana Zuvela-Jelaska، نويسنده , , John Proudfoot، نويسنده , , Gerald Nabozny، نويسنده , , David Thomson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
5091
To page
5095
Abstract
We have recently reported the discovery of a novel class of glucocorticoid receptor (GR) antagonists, exemplified by 3, containing a 1,2-dihydroquinoline molecular scaffold. Further SAR studies of these antagonists uncovered chemical modifications conveying agonist functional activity to this series. These agonists exhibit good GR binding affinity and are selective against other nuclear hormone receptors.
Keywords
Glucocorticoid receptor , agonist , SAR
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798559
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