Title of article
A synthetic entry to pladienolide B and FD-895
Author/Authors
Alexander L. Mandel، نويسنده , , Brian D. Jones، نويسنده , , James J. La Clair، نويسنده , , Michael D. Burkart، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
5159
To page
5164
Abstract
Presented within are syntheses of the pladienolide B and FD-895 side-chains, as well as models of the essential ring-closing metathesis and Stille coupling that will be used to complete their total syntheses. Several analogs of the pladienolide B side-chain were also prepared in order to evaluate the scope of the methodology and to create a library of structures that could be used for stereochemical and SAR analyses.
Keywords
Antitumor agents , metathesis , Analogs , Macrolides , natural products
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798574
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