Title of article
Pyrrolidines as potent functional agonists of the human melanocortin-4 receptor
Author/Authors
Joe A. Tran، نويسنده , , Caroline W. Chen، نويسنده , , Wanlong Jiang، نويسنده , , Fabio C. Tucci، نويسنده , , Beth A. Fleck، نويسنده , , Dragan Marinkovic، نويسنده , , Melissa Arellano، نويسنده , , Chen Chen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
5165
To page
5170
Abstract
A series of pyrrolidine derivatives were synthesized and characterized as potent agonists of the human melanocortin-4 receptor. For example, 28c had a Ki of 13 nM in binding affinity and EC50 of 6.9 nM in agonist potency with an intrinsic activity of 100% of the endogenous ligand α-MSH.
Keywords
agonist , synthesis , melanocortin-4 receptor , pyrrolidine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798575
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