Author/Authors :
Simon E. Ward، نويسنده , , Christopher N. Johnson، نويسنده , , Peter J. Lovell، نويسنده , , Claire M. Scott، نويسنده , , Paul W. Smith، نويسنده , , Geoffrey Stemp، نويسنده , , Kevin M. Thewlis، نويسنده , , Antonio K. Vong، نويسنده , , Jeannette M. Watson، نويسنده ,
Abstract :
A series of 5-(piperidinylethyloxy)quinoline 5-HT1 receptor ligands have been studied by elaboration of the series of dual 5-HT1-SSRIs reported previously. These new compounds display a different pharmacological profile with potent affinity across the 5-HT1A, 5-HT1B and 5-HT1D receptors and selectivity against the serotonin transporter. Furthermore, they have improved pharmacokinetic profiles and CNS penetration.
Keywords :
5-HT , Serotonin , autoreceptors , depression
