Title of article
Discovery and SAR studies of novel GlyT1 inhibitors
Author/Authors
Magnus W. Walter، نويسنده , , Beth J. Hoffman، نويسنده , , Kimberly Gordon، نويسنده , , Kirk Johnson، نويسنده , , Patrick Love، نويسنده , , Matthew Jones، نويسنده , , Teresa Man، نويسنده , , Lee Phebus، نويسنده , , Jon K. Reel، نويسنده , , Helene C. Rudyk، نويسنده , , Harlan Shannon، نويسنده , , Kjell Svensson، نويسنده , , Hong Yu، نويسنده , , Matthew J. Valli، نويسنده , , Warren J. Porter، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
5233
To page
5238
Abstract
Inhibition of the glycine transporter GlyT1 is a potential strategy for the treatment of schizophrenia. A novel series of GlyT1 inhibitors and their structure–activity relationships (SAR) are described. Members of this series are highly potent and selective transport inhibitors which are shown to elevate glycine levels in cerebrospinal fluid.
Keywords
Glycine transporter , GlyT1 , Schizophrenia , GlyT2
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798589
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