Title of article
Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile
Author/Authors
Eva ?gai-Csongor، نويسنده , , Katalin N?gr?di، نويسنده , , Janos Galambos، نويسنده , , Istv?n V?g?، نويسنده , , Attila Bielik، نويسنده , , Ildik? Magd?، نويسنده , , Gy?rgyi Ign?cz-Szendrei، نويسنده , , Gy?rgy Mikl?s Keser?، نويسنده , , Istv?n Greiner، نويسنده , , Istv?n Laszlovszky، نويسنده , , Eva Schmidt Béla Kiss، نويسنده , , Katalin S?ghy Judit Laszy، نويسنده , , Istv?n Gyerty?n، نويسنده , , M?ria Z?jer-Bal?zs، نويسنده , , Larisza Gémesi، نويسنده , , Gy?rgy Dom?ny، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
5340
To page
5344
Abstract
A novel series of arylsulfonamides was prepared either by automated parallel or by traditional solution-phase synthesis. Several members of this compound library were identified as high-affinity dopamine D3 and D2 receptor ligands. The most interesting representative, compound 2, showed potent antipsychotic behaviour coupled with a beneficial cognitive and EPS profile.
Keywords
Arylsulfonamides , Cognition enhancer , Dopamine D3 and D2 ligands , Antipsychotic
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798609
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