Title of article
1,2,4-Benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: Synthesis, DNA-binding affinity and cytotoxicity
Author/Authors
Ahmed Kamal، نويسنده , , M. Naseer A. Khan، نويسنده , , K. Srinivasa Reddy، نويسنده , , S. Kaleem Ahmed، نويسنده , , M. Shiva Kumar، نويسنده , , Aarti Juvekar، نويسنده , , Subrata Sen، نويسنده , , Surekha Zingde، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
5345
To page
5348
Abstract
Benzothiadiazine–pyrrolobenzodiazepine conjugates linked through different alkane spacers have been prepared. These new classes of hybrid molecules exhibit cytotoxicity against many cancer cell lines. Their DNA thermal denaturation studies have been carried out and one of the compounds (4b) elevates the DNA helix melting temperature of the CT-DNA by 6.7 °C after incubation for 36 h.
Keywords
Pyrrolobenzodiazepines , Benzothiadiazines , Cytoxicity , DNA binding
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798610
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